Inflammation is induced by chemical mediators that are produced by host cells in response to injurious stimuli.The external manifestations of inflammation, often called its cardinal signs, are heat (calor in Latin), redness (rubor), swelling (tumor), pain (dolor), and loss of function (functio laesa). When acute inflammation achieves its desired goal of eliminating the offenders, the reaction subsides and residual injury is repaired. Its main characteristics are the exudation of fluid and plasma proteins (edema) and the emigration of leukocytes, predominantly neutrophils (also called polymorphonuclear leukocytes). It typically develops within minutes or hours and is of short duration, lasting for several hours or a few days.
The initial, rapid response to infections and tissue damage is called acute inflammation.
The reaction is controlled and terminated. The leukocytes and proteins are activated and work together to destroy and eliminate the offending substance. Leukocytes and plasma proteins are recruited from the circulation to the site where the offending agent is located. The offending agent, which is located in extravascular tissues, is recognized by host cells and molecules. The typical inflammatory reaction develops through a series of sequential steps: 1. Inflammation is a response of vascularized tissues to infections and tissue damage that brings cells and molecules of host defense from the circulation to the sites where they are needed, to eliminate the offending agents.
0 kommentar(er)
